As women age their reserve of eggs available for ovulation naturally declines. 1 in 10 women will experience significant decline earlier than they should. Those at risk include people with autoimmune disorders (e.g. thyroid disease, rheumatoid arthritis), endometriosis and previous operations involving their ovaries.
Patients with POA have difficulty conceiving naturally, or even with fertility treatment, especially if the treatment is not appropriate for their fertility status. However, timely diagnosis with the appropriate individualised treatment can make conception possible in many cases. Early treatment is important because the decline in reserve can be quite rapid.
A simple blood test (AMH, FSH) and ultrasound scan (antral follicle count) with age-specific interpretation will diagnose the condition.